| 摘要 |
<p>The invention concerns a fast-disintegrating tablet such as those designed to dissolve in the mouth in contact with saliva in less than 30 seconds forming an easy-to-swallow suspension and based on an active substance in the form of coated microcrystals or microgranules and a mixture of carriers comprising at least a disintegrating agent, a soluble agent and a lubricating agent. The invention is characterised in that the lubricating agent is in powder form and is distributed at least for the greater part at the tablet surface and its friability measured as specified in the French codex (10th edition, V.5.1- Friability of tablets , January 1993) is less than 1 %, preferably less than 0.5 %, whereby said tablet can be packaged with standard means and has the required and adequate hardness to enable it to be extracted from its bubble card wherein it is packed by perforating the seal thereof by pushing the tablet with substantially reduced risk of being broken when it is being extracted. The invention also concerns the method for making said tablet.</p> |
