4-HETEROCYCLYSULFONAMIDYL-6-METHOXY-5-(2-METHOXY-PHENOXY)-2-PYRIDYL-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN RECEPTOR ANTAGONISTS

摘要

The compounds of formula (I) wherein R1 is a heterocyclic residue selected form pyridil and thiazolyl, where said heterocyclic residue may optionally b e substituted with lower alkyl or lower alkenyl; and pharmaceutically acceptab le salts thereof, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction; and the corresponding intermediat es of formulae (III) and (V).