Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
申请公布号
WO0051564(A1)
申请公布日期
2000.09.08
申请号
WO2000US05546
申请日期
2000.03.02
申请人
ELI LILLY AND COMPANY;MILTON, NATHANIEL;MODER, KENNETH, PHILIP;SABATOWSKI, JAMES, LAWRENCE;SWEETANA, STEPHANIE, ANN
发明人
MILTON, NATHANIEL;MODER, KENNETH, PHILIP;SABATOWSKI, JAMES, LAWRENCE;SWEETANA, STEPHANIE, ANN