BLOOD SERUM SAMPLE PREPARED FOR ISOLATION OF PRIONS AND PRPSC

摘要

A sample is prepared from blood in a manner which makes it possible to furth er analyze proteins in the sample, e.g. to detect prions in the sample. Blood i s extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain serum. The serum is treated with a complexing agen t which binds prions in the sample forming an agent/protein complex which make s it possible to concentrate the complex. Concentration of the complex results in a sample which can be successfully analyzed, e.g. assayed using a range o f different types of assay methodologies for detecting prions (see the figure) .