TREATMENT OF ADDICTION AND ADDICTION-RELATED BEHAVIOR

摘要

The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to abused drugs, such as cocaine, nicotine, methamphetamine, ethanol, morphine, heroin and combinations thereof. The method includes administering to the mammal an effective amount of a compound increasing central nervous system GABA levels, wherein the effective amount is sufficient to diminish, inhibit or eliminate behavior associated with craving or use of abused drugs. Said compound may be gamma vinyl GABA (GVG), a pharmaceutically acceptable salt thereof, or an enantiomer or a racemic mixture thereof, or may be gabapentin, valproic acid, progabide, gamma-hydroxybutyric acid, fengabine, cetyl GABA, topiramate, tiagabine, acamprosate, pharmaceutically acceptable saltsthereof, enantiomers or racemic mixtures thereof.