| 摘要 |
<p>The invention relates to a method for producing glyco-conjugates of 20(S)-camptothecin in which a 3-O-methylated beta -L-fucose building block is linked to the 20 hydroxyl group of a camptothecin derivative via thiourea-modified peptide spacers, whereby the decisive step exists in the linking of the building block (II) with the building block (V) in the presence of a particular coupling reagent such as N-[(dimethylamino)-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-m ethylmethane-aminium hexafluorophosphate-N-oxide (HATU).</p> |
