| 摘要 |
DNA sequences (A) of the dltABCD operons from Staphylococcus xylosus (about 5.4 kb; 2)and S. aureus (about 5.9 kb; 3), both reproduced, are new. Independent claims are also included for the following: (a) DNA sequences (A') that hybridize to (2), (3) or their fragments under stringent conditions; (b) DNA sequences (A'') that encode any of 10 specified peptide sequences, reproduced; (c) DNA sequences (B) derived from (A), (A') or (A'') by at least one mutation, particularly an insertion or deletion, especially in the coding region; (d) gene products (C) from (A), (A'), (A'') and (B); (e) peptides (D) specified in (b); (f) vectors containing (A), (A'), (A'') and (B); (g) organisms, particularly bacteria, that have altered expression of at least one gene that encodes a protein involved in incorporation of D-alanine (Dala) into teichoic acid (I); (h) (I) expressed in the organisms of (g) and/or having a structure different from that of wild-type (I); (i) an active agent (II) that (in)directly modulates or specifically reduces, the activity of (I), especially its inflammatory activity on cells; (j) an active agent (II') that modulates or specifically increases, the sensitivity of microbes to antimicrobial agents; (k) a pharmaceutical composition containing at least one (II) or (II') and optionally a carrier; and (l) a method for identifying (II) or (II').
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