发明名称 |
Methods for producing protein C |
摘要 |
<p>The present invention relates to a method for producing high levels of functional recombinant proteins in adenovirus-transformed mammalian cells by incubating cells capable of producing recombinant proteins at a temperature range between about 38 degrees centigrade and about 39 degrees centigrade. The method allows for higher levels of expression of total protein in some cell lines and higher levels of functional protein in other cell lines.</p> |
申请公布号 |
EP0658626(B1) |
申请公布日期 |
2000.09.06 |
申请号 |
EP19940309314 |
申请日期 |
1994.12.14 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
GRINNELL, BRIAN WILLIAM |
分类号 |
C12N15/09;C07K14/745;C12N5/00;C12N5/06;C12N5/10;C12N5/16;C12N9/64;C12N15/06;C12N15/12;C12N15/57;C12N15/63;C12N15/67;C12N15/85;C12P21/00;C12P21/02;C12R1/91;(IPC1-7):C12N15/57 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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