发明名称 |
Human pluripotent hematopoietic colony stimulating factor and cell line producing same |
摘要 |
Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5x108 U/mg protein.
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申请公布号 |
US6114166(A) |
申请公布日期 |
2000.09.05 |
申请号 |
US19970996051 |
申请日期 |
1997.12.22 |
申请人 |
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
WELTE, KARL;PLATZER, ERICH;GABRILOVE, JANICE L.;MERTELSMANN, ROLAND;MOORE, MALCOLM A. S. |
分类号 |
A61K38/00;A61K38/18;A61K38/19;C07H21/04;C07K1/14;C07K1/18;C07K1/22;C07K1/30;C07K14/435;C07K14/475;C07K14/52;C07K14/53;C07K14/535;C07K14/575;C12N5/08;C12P21/02;(IPC1-7):C12N5/08 |
主分类号 |
A61K38/00 |
代理机构 |
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