METHOD FOR THE PURIFICATION OF INTACT, CORRECTLY-FOLDED INSULIN-LIKE GROWTH FACTOR-1

摘要

Method for the recovery and purification of intact, correctly-folded, monomeric insulin-like growth factor-1 peptide from large volumes of 1GF-1-containing medium are described, comprising a series of adsorption-desorption steps employing a combination of cation exchange and hydrophobic interaction adsorbents. Product IGF-1 peptide is highly purified and suitable for use in a variety of clinical applications.