发明名称 |
METHOD FOR REMOVING ORGANIC SOLVENT REMAINING IN FINE PARTICLE |
摘要 |
PROBLEM TO BE SOLVED: To efficiently and almost completely remove an organic solvent remaining in fine particles in a short time by heating the fine particles in which an organic solvent having a lower boiling point than water is contained in a water phase at a temperature higher than the boiling point of the organic solvent. SOLUTION: An organic solvent (preferably an organic solvent having a boiling point >=10 deg.C less than that of water, e.g. a halogenated aliphatic hydrocarbon-based solvent) remaining in fine particles consisting of an agent and a polymer (e.g. the polyester of a hydroxyfatty acid) hardly soluble in water is removed by heating the fine particles in a water phase at a temperature higher than the boiling point of the organic solvent (preferably at a temperature >=5 deg.C higher than the boiling point). The initial residual amount of the organic solvent in the fine particles is preferably <=40 wt.%. The ratio of the fine particles to the water phase is preferably 0.1-1000 g per 1 litter of the water phase without containing the fine particles. Thus, highly safe fine particle formulations are easily provided.
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申请公布号 |
JP2000239152(A) |
申请公布日期 |
2000.09.05 |
申请号 |
JP19990039599 |
申请日期 |
1999.02.18 |
申请人 |
TANABE SEIYAKU CO LTD |
发明人 |
MIZOBE MASAKAZU;YOSHINO KOUSUKE;YAMAMOTO TOSHIHIRO;MATSUKAWA YASUHISA;TANIMOTO MASAHIKO |
分类号 |
A61K9/00;(IPC1-7):A61K9/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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