SUPERCRITICAL EXTRACTANT COMPOSITE FOR REMOVING POLAR IMPURITIES OF A COMPOUND FOR ORAL USE

摘要

PURPOSE: A supercritical extractant composite for removing polar impurities of a compound for oral use composite is provided to mix carbon monoxide ,which is effective to remove a resident solvent of solid compound for oral use, with a polar solvent, which is not harmful for human health. CONSTITUTION: A supercritical extractant composite for removing polar impurities of a compound for oral use is processed to mix carbon monoxide under 90 volume percent with a polar solvent or with more than two solvents which are liquid phase at room temperature and which has boiling point under 200°C. The composite is manufactured to maintain at 74-800 atm and at 32-200°C. The polar solvent is selected from methanol, ethanol, other alcohol groups and acetic acid, formic acid, organic acid groups and water.