发明名称 |
Viral (HIV) growth inhibition |
摘要 |
A synthetic molecule comprises at least one oligonucleotide, comprising and RNA binding sequence or sequences corresponding to the site bound by the HIV protein tat and capable of binding to tat within cells. The binding sequence or sequences, by binding tat within cells, can act to cause inhibition of growth of any HIV present in the cells, and so has potential therapeutic use in treatment of patients affected with HIV. The invention also provides an assay for identifying compounds that inhibit tat binding.
|
申请公布号 |
US6114109(A) |
申请公布日期 |
2000.09.05 |
申请号 |
US19980083756 |
申请日期 |
1998.05.22 |
申请人 |
RIBOTARGETS, LTD. |
发明人 |
KARN, JONATHAN;GAIT, MICHAEL J.;HEAPHY, SHAUN;DINGWALL, COLIN |
分类号 |
A61K31/70;A61K48/00;A61P31/12;A61P31/18;C07K14/16;C12N15/09;C12N15/115;C12N15/67;C12Q1/68;C12Q1/70;G01N33/15;G01N33/53;G01N33/566;(IPC1-7):C12Q1/00 |
主分类号 |
A61K31/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|