发明名称 |
Process for the preparation of tetraazamacrocycles |
摘要 |
A process for the preparation of tetraazamacrocycles of general formula (I) wherein n, p and q can independently be 0 or 1, comprising the following steps: a): condensation of polyamines with a glyoxal derivative; b): condensation of the resulting compound with an alkylating agent; c): oxidation of the resulting compound with an oxidizing agent, to give a mixture of oxidated products which is submitted to d): hydrolysis in acid aqueous solution, to give the compound of formula (I).
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申请公布号 |
US6114521(A) |
申请公布日期 |
2000.09.05 |
申请号 |
US19980203595 |
申请日期 |
1998.12.02 |
申请人 |
DIBRA S.P.A. |
发明人 |
ARGESE, MARIA;RIPA, GIORGIO;SCALA, ALESSANDRO;VALLE, VITTORIO |
分类号 |
C07D257/02;C07D487/22;(IPC1-7):C07D487/22 |
主分类号 |
C07D257/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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