发明名称 |
Thiol-derivatized oligonucleotides |
摘要 |
Nucleosides and linked nucleosides functionalized to include alkylthiol chemical functionality at ribofuranosyl positions, nucleosidic base positions, or on internucleoside linkages. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the alkylthio group.
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申请公布号 |
US6114513(A) |
申请公布日期 |
2000.09.05 |
申请号 |
US19970924326 |
申请日期 |
1997.09.05 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
COOK, PHILLIP DAN;MANOHARAN, MUTHIAH |
分类号 |
A61K38/00;A61K48/00;C07H19/04;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H21/00;C07H21/02;C07H21/04;C07H23/00;C07J43/00;C07J51/00;C12N9/02;C12N15/113;C12Q1/68;(IPC1-7):C07H21/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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