| 摘要 |
A synergistic composition and a synergistic system for use in treating the skin and hair of people and animals comprises separate treatment compositions (solution, dispersions, emulsions, suspensions or other liquid or liquefiable materials). One treatment with a first composition that may comprise at least 0.1% by weight of antimicrobially active aliphatic phenol derivative and treatment with another composition being selected from the group consisting of: a) a solution comprising an antimicrobially active cationic species; b) a comprising antimicrobially active aliphatic phenol derivative, preferably in a different weight percentage of antimicrobially active aliphatic phenol derivative than said one composition, comprising greater than 0.3% antimicrobially active aliphatic phenol derivative; c) a solution comprising an alcohol provides a synergistic antimicrobial action. These compositions do not have to be applied in any particular order, and more than two compositions may be combined in separate or sequential applications. The single compositions of the present invention comprise, for example, a single composition comprising at least 0.1% by weight Triclosan and at least one synergistic additive selected from the group consisting of chlorhexidene gluconate, solutions with greater than 0.3% Triclosan and an alcohol. These compositions, both as single compositions or as separate compositions have been found to provide synergistic antimicrobial effects. It is surprising that even when the separate compositions are applied with significant periods of time between application of the individual compositions (e.g., 2, 3, 5 or even 8 hours between applications) a synergistic effect may be provided. This is believed to be at least in part because some of the materials may persist on the skin and later would be combined with the application of the other synergistic composition. Because of the unique ability to provide synergy in separate compositions, with gaps in time between application of the separate materials, a system of washing, cleansing, lubricating, and moisturizing compositions may be provided within a health care complex. In this manner, as an individual applies the various compositions over the course of the day, due to varying activity, not only will an individual application of antimicrobial agent occur, but a synergistic effect can be initiated. |
