摘要 |
The object of the present invention is to provide a method for screening a vitamin D derivative which has a limited or no blood calcium increasing action, while retaining its useful physiological activities. According to the present invention, there is provided a method for screening a compound having an affinity for a vitamin D receptor, comprising measuring a vitamin D receptor-associated, VDRE-mediated transcription promoting activity of a test compound and a vitamin D receptor-associated inhibitory action of the test compound against activity of a transcription factor; and selecting a compound which is more potent in inhibitory action against the activity of the transcription factor than in VDRE-mediated transcription promoting activity. |