Novel inhibitors of potassium flux are disclosed. The inhibitors show surprising resistance to degradation in biological media and enhanced in vivo half-lives relative to non-fluorine substituted homologues. Methods for the use of these compounds include treating sickle cell disease, preventing erythrocyte dehydration and inhibiting potassium flux.
申请公布号
WO0050026(A1)
申请公布日期
2000.08.31
申请号
WO2000US03663
申请日期
2000.02.10
申请人
ICAGEN, INC.;MCNAUGHTON-SMITH, GRANT, ANDREW;RIGDON, GREGORY, COOKSEY;STOCKER, JONATHAN, WALTER
发明人
MCNAUGHTON-SMITH, GRANT, ANDREW;RIGDON, GREGORY, COOKSEY;STOCKER, JONATHAN, WALTER