CARBOHYDRATE-MODIFYING ENZYMES FOR BURN AND WOUND DEBRIDEMENT AND METHODS FOR TREATMENT

摘要

The present invention features a method for treating wounds comprising the step of administering an effective amount of a carbohydrate-active enzyme. In another aspect, the present invention features pharmaceutical compositions for treating wounds. The invention also features cDNA sequences for carbohydrate-active enzymes and cDNA expression systems for using various DNA sequences to produce mammalian carbohydrate-active enzymes for a variety of uses. The invention further includes recombinant plasmids comprising the cDNA of mammalian carbohydrate-active enzymes. The invention also includes transformed cells comprising a heterologous DNA sequence that encodes for a carbohydrate-active enzyme or a biologically active fragment or mutant thereof. Preferred carbohydrate-active enzymes according to the present invention include chondroitinases and hyaluronidases.