ENHANCEMENT OF BACTERICIDAL ACTIVITY OF NEISSERIA ANTIGENS WITH OLIGONUCLEOTIDES CONTAINING CG MOTIFS

摘要

Immunogenic compositions (e.g. vaccines) comprising: (a) an immunostimulatin g amount of a Neisseria antigen (preferably N. meningitidis serogroup B); and (b) an immunostimulating amount of an adjuvant composition comprising an oligonucleotide comprising at least one CG motif. Component (b) may further comprise a second adjuvant. Component (a) may be selected from a variety of antigens. Adjuvant compositions comprising an oligonucleotide having at leas t one CG motif, and complete Freund's adjuvant (CFA) are also provided.