CHIRAL DIAZAPHOSPHOLIDINE LIGANDS

摘要

The application relates to diazaphospholidine compounds of Formula (1) and Formula (2) where A and B are independently selected from C(R22R23) and C(R22R23)C(R24R25); R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and R25 each may or may not be present and each may be independently selected from H, halide -OH, -SO2R26 (where R26 is selected from a group as defined for R22, R23, R24 and R25), -SH, -NO2, -NH2, =O, =S, straigh chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, hydroalkyl, carboalkyl, alkoxy, amino, alkenyl, aryl and -CH2 Ar (where Ar is aryl or substituted aryl), preferably containing 1 to 6 carbons, or a silane containing 1 to 6 silicon atoms, wherein, where an R1, R2, R3, R4, R18, R19, R20, R21, R22, R23, R24 and/or R25 group is not present an unsaturated bond is formed; R5 and R17 are selected from H, -NH2, -OH, halide or a substituted or non-substituted straight or branched chain alkyl or aryl; R6, R7, R15 and R16 are each independently selected from halide -OH, -SO2, -SH, -NO2, -NH2, straight chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, carboalkyl, alkoxy, alkenyl, aryl and -CH2 Ar (where Ar is aryl or substituted aryl), or a silane containing 1 to 6 silicon atoms; R8 and R14 are selected from H, straight, branched, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, carboalkyl, alkoxy, alkenyl, aryl and -CH2 Ar (where Ar is aryl or substituted aryl); R9, R10, R11, R12, R13 are independently selected from halide -OH, -SO2, -SH, -NO2, -NH2, straight chain, branched chain, cyclic, saturated, non-saturated, substituted or non-substituted alkyl, carboalkyl, alkoxy, amino, alkenyl, aryl and -CH2 Ar (where Ar is aryl or substituted aryl), or a silane containing 1 to 6 silicon atoms; and X is a linking group containing 1 to 12 atoms; or a salt thereof. These compounds may be used as catalysts for asymmetric catalyst of organic reactions.