OLIGOPEPTIDE DERIVATIVES FOR THE ELECTROCHEMICAL MEASUREMENTOF PROTEASE ACTIVITY

摘要

The invention relates to oligopeptide derivatives whose C-terminal amino aci d is arginine which is linked to the remainder of an electroactive aniline or aminoquinoline derivative by an amide bond. Said oligopeptide derivatives ar e split by enzymes of the class of peptide hydrolases, especially proteinases and their inhibitors, of the coagulation system, the fibrinolytic system and the complement, especially of thrombin. These oligopeptide derivatives therefore serve as a substrates for quantitatively determining such enzymes, especially thrombin, in complex sample liquids, especially capillary blood. This determination is carried out by measuring the increase in the water- soluble amperogenic aniline or aminoquinoline compound. The oligopeptide derivative and their salts can be produced according to usual methods in peptide chemistry.