TREATMENT REGIMEN FOR HORMONE-SENSITIVE CANCERS

摘要

This invention provides for a novel schedule and dosage regimen of the combination paclitaxel-estramustine and chemical or surgical hormone depletion to treat patients with advanced breast cancer who have not received previous therapy and are candidates for hormonal therapy. This invention differs from all current treatment strategies by the intercalation of cytotoxic chemotherapy (preferably paclitaxel and estramustine) at a specified interval (two months; range 2 weeks to 6 months) after initiation of hormone depletion therapy.