摘要 |
A dihydroquinazoline derivative of formula (I), or a pharmaceutically acceptable salt thereof, wherein: either R1 and R1' together form an oxo gro up and R2 is hydrogen, C1-C4 alkyl, -(C1-C4 alkyl)-COB, -(C1-C4 alkyl)-CO-(C1-C 4 alkyl)-B, -(C1-C4 alkyl)-CO2-(C1-C4 alkyl)-B, -(C1-C4 alkyl)-CO2-(C2-C4 alkenyl)-B or -(C1-C4 alkyl)-CONH-(C1-C4 alkyl)-B wherein B is -CO2H, hydrox y, C1-C4 alkoxy, amino, (C1-C4 alkyl)amino, di(C1-C4 alkyl)amino or a 5- or 6- membered heterocyclic group, or R1' and R2 together form a bond and R1 is -S - (C1-C4 alkyl), -NHR' or -NHCOR' wherein R' is aryl or C1-C4 alkyl; R3 is - (CH2)p-A wherein p is from 1 to 4 and A is a 5- or 6-membered N-containing heterocyclic ring attached via the N atom or A is -NA'A" wherein A' and A" a re the same or different and are each a C1-C4 alkyl group; either R4 is hydroge n, oxo or C1-C4 alkyl and R5 is hydrogen, C1-C4 alkyl or halogen, or R4 and R5, together with the carbon atoms to which they are attached, form a 5- or 6- membered carbocyclic ring; X1 is -O-, -S- or -NR"- wherein R" is hydrogen, C 1- C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl; Y is a divalent aryl or heteroaryl group; R6 is hydrogen, oxo or C1-C4 alkyl; X2 is -O-, -S- or -NR"- wherein R " is as defined above; m is from 1 to 4; and R7 is pyridyl, pyrimidyl, imidazolyl, triazolyl, -(C1-C4 alkyl)-imidazolyl, or -(C1-C4 alkyl)-triazoly l.
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