ADENOVIRAL VECTORS, PROTEINS AND METHODS FOR THEIR USE

摘要

Purified proteins that function in viral replication, especially in controlling the viral latent state, are provided. Nucleotide sequences encoding these proteins are also provided. Both DNA sequences, and the RNA transcripts are encompassed by the invention. The invention also provides recombinant vectors including the nucleotide sequence encoding the novel proteins described herein. In a preferred form of the invention, a plasmid is provided that includes the nucleotide squence encoding the novel proteins described herein, along with an adenoviral origin of replication. Further provided are host cells that include the recombinant vectors described herein, adenoviral vectors and methods of expressing viral proteins and other desired proteins utilizing the nucleotide sequences, recombinant vectors and host cells described herein.