发明名称 |
Protese-activated receptor PAR4 (ZCHEMR2) |
摘要 |
The present invention relates to polynucleotide and polypeptide molecules for PAR4, a novel member of the protease-activated receptor family. The polypeptides, and polynucleotides encoding them, mediate biological responses and/or cellular signaling in response to proteases. Protease cleavage of PAR4 exposes a PAR4 extracellular amino terminal portion that serves as a ligand for the PAR4 receptor. PAR4 may be used as a target in drug screening, and further used to identify proteinaceous or non-proteinaceous PAR4 agonists and antagonists. The present invention also includes antibodies to the PAR4 polypeptides.
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申请公布号 |
US6111075(A) |
申请公布日期 |
2000.08.29 |
申请号 |
US19980053866 |
申请日期 |
1998.04.01 |
申请人 |
ZYMOGENETICS, INC.;UNIV WASHINGTON |
发明人 |
XU, WEN-FENG;PRESNELL, SCOTT R.;YEE, DAVID P.;FOSTER, DONALD C. |
分类号 |
A61K38/00;C07K14/705;C12N15/12;(IPC1-7):C07K7/06;C07K7/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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