发明名称 |
Sustained release salts of pharmaceutically active peptides and their production |
摘要 |
Substained delivery pharmaceutical compositions comprise a water insoluble salt of a pharmaceutically active ionic peptide and a counterionic carrier macromolecule. The peptide may be an LHRH antagonist such as cetrorelix and the macromolecule may be an anionic polysaccharide such as carboxymethylcellulose. The salt is prepared using ion exchangers to sepArately remove the counterions from the peptide and the carrier macromolecule thereby forming free peptide/macromolecule ions. These free peptide and macromolecule ions are then combined to form the water insoluble peptide-macromolecule salt. |
申请公布号 |
AU2799700(A) |
申请公布日期 |
2000.08.29 |
申请号 |
AU20000027997 |
申请日期 |
2000.01.29 |
申请人 |
ASTA MEDICA AKTIENGESELLSCHAFT |
发明人 |
HORST BAUER;WOLFGANG DEGER;WERNER SARLIKIOTIS;MICHAEL DAMM |
分类号 |
A61K9/10;A61K9/14;A61K9/19;A61K38/00;A61K38/09;A61K47/30;A61K47/32;A61K47/36;A61K47/38;A61K47/42;A61K47/48;A61P43/00 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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