发明名称 |
DNA encoding precursor of interleukin-1 beta converting enzyme-related cysteine proteinase II (ICErel-II) |
摘要 |
A complementary DNA (cDNA) encoding full length form of ICErel-II is identified, sequenced and isolated. The cDNA is cloned into expression vectors for expression in recombinant hosts. The cDNA is useful to produce recombinant full length ICErel-II. The cDNA and the recombinant ICErel-II protein derived therefrom are useful in diagnostic kits, laboratory reagents and assays. The cDNA and the recombinant ICErel-II protein may be used to identify compounds that affect ICErel-II function, inflammation and cell apoptosis. ICErel-II function, inflammation and cell apoptosis may also be modulated by ICErel-II antisense or gene therapy.
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申请公布号 |
US6110701(A) |
申请公布日期 |
2000.08.29 |
申请号 |
US19940225487 |
申请日期 |
1994.04.08 |
申请人 |
MERCK FROSST CANADA & CO. |
发明人 |
NICHOLSON, DONALD W.;ALI, AMBEREEN;MUNDAY, NEIL A.;VAILLANCOURT, JOHN P. |
分类号 |
C12N15/09;A61K38/00;A61K38/46;A61K48/00;A61P3/00;A61P9/00;A61P25/00;A61P25/28;A61P31/04;A61P35/00;A61P43/00;C07K16/40;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/64;C12N15/57;C12Q1/37;C12Q1/68;C12R1/19;C12R1/91;(IPC1-7):C12N15/00;C12N15/63;C12N1/20;C07H21/04 |
主分类号 |
C12N15/09 |
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