Avermectin derivatives

摘要

Avermectin derivatives represented by the general formula (I) or salts thereof: wherein -X----Y- represents -CH=CH-, -CH2-C(=O)-, -CH2-CH2-, or -CH2-CH(R<13>)-; for example, 1) when -X----Y- represents -CH=CH-, R<1> represents (R<11>)(R<12>)C Äwherein R<11> represents a substituted or unsubstituted lower alkyl group; a formyl group; a lower alkoxylcarbonyl group etc.; and R<12> represents a hydrogen atom or a lower alkyl groupÜ; when the bond between R<2> and a carbon atom at the 5-position is a single bond, R<2> represents a hydroxyl group or a tri(lower alkyl)silyloxy group; or R<2> forms a carbonyl group or a hydroxime group together with the carbon atom at the 5-position; 2) when -X----Y- represents -CH2-C(=O)-, R<1> represents (R<11a>)(R<12a>)C Äwherein R<11a> represents a lower alkoxycarbonyl group, or -COOCH2CH=CH2; and R<12a> represents a hydrogen atomÜ; and R<2> represents a hydroxyl group or a tri(lower alkyl)silyloxy group.