| 摘要 |
Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence: - (SEQ ID NO:2) - 5 10 - Ala Thr Leu Xaa Xaa Val His Xaa Xaa Ile Xaa Xaa Xaa - - 15 20 25 - Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu Glu Gln - - 30 35 - Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr - wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
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