发明名称 |
Cytoskeletal active agents for glaucoma therapy |
摘要 |
Methods for the treatment of glaucoma are described. The compounds described cause a perturbation of cell adhesions in the trabecular meshwork, mainly via disruption of the associated cytoskeletal structures or the modulation of their interactions with the underlying membrane. Perturbation of these adhesions reduces the resistance of the trabecular meshwork to fluid flow and thereby reduces intraocular pressure.
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申请公布号 |
US6110912(A) |
申请公布日期 |
2000.08.29 |
申请号 |
US19980022228 |
申请日期 |
1998.02.11 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
KAUFMAN, PAUL L.;GEIGER, BENJAMIN |
分类号 |
A61K31/00;A61K31/365;A61K31/403;A61K31/407;A61K31/427;A61K31/496;A61K31/551;A61K45/06;(IPC1-7):A61K31/55 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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