| 摘要 |
A member of the tumor necrosis factor family and associated antibodies and uses are described. This member is primarily expressed in B cells and its expression correlates to increases in the number of B cells and immunoglobulins produced. The human ortholog contains 285 amino acids; the mouse ortholog, 309 amino acids. The protein is a type II transmembrane protein and has an amino terminal cytoplasmic domain, a transmembrane domain, and a carboxy terminal extracellular domain. TNF-related proteins of the invention may be membrane-associated or in soluble form, recombinantly produced or isolated after natural production. The invention provides for nucleic acids encoding such TNF-related proteins, vectors and host cells expressing the polypeptides, and methods for producting recombinant porteins. Antibodies, fragments, and related fusion proteins and derivatives may be used as agonists or antagonists of AGP-3 related activity. |
