Treating diseases characterised by changes in intercellular adhesion molecules using coding sequences hybridizable with those encoding proteins involved in synthesis of such molecules

摘要

The specification describes antisense oligonucleotides as research reagents for investigating disease states which respond to modulation of the synthesis or metabolism of cell adhesion molecules and their use in therapies for treating psoriasis, inflammatory bowel disease and melanomas. Molecules of interest include ICAM-1, ELAM-1 (E-selectin) and VCAM-1.