| 摘要 |
PURPOSE: A method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules is provided. CONSTITUTION: Provided is a method for preparing nanoparticles formed of a statistic polymer of at least one compound of formula (I) in which A represents a group (a) or a group (b); R1 and R2, identical or different, represent a C1-C6 alkyl group linear or branched; n = 1, 2, 3, 4, or 5, characterised in that the monomer is previously made soluble in an organic aprotic solvent miscible in water forming with the polymerisation medium a mixture non-solvent of the formed polymer. Also the nanoparticles, containing optionally one or several biologically active molecules, and the pharmaceutical compositions containing them are provided.
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