发明名称 Dihydro- and tetrahydro-quinoline compounds
摘要 Compounds of the formula above are useful as anti-oxidants. R1 is hydrogen or -(C)-NH-A; A is hydrogen or -BNZ1Z2; B is a alkylene group; Z1 and Z2 independently are selected from hydrogen, alkyl, cycloalkyl or optionally substituted aryl, or together with the nitrogen atom to which they are bound, form an optionally substituted heterocycloalkyl or heteroaryl group; R2 and R3 each independently are selected from alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and aminoalkyl , or R2 and R3 together with the carbon atom to which they are bound form a cycloalkyl or an optionally substituted monocyclic heterocycloalkyl group; R40 is a hydrogen atom, optionally substituted alkyl, alkenyl or alkynyl, Q or -V-Q; V is alkylene, alkenylene or alkynylene; Q is optionally substituted cycloalkyl, aryl, heterocycloalkyl or heteroaryl; R41 and R5 together form a bond or are each hydrogen; R6, R7, R8 and R9 are each independently hydrogen, halogen, alkyl, cycloalkyl or -OW; W is hydrogen, alkyl, acyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, heteroaryl, arylalkyl, heteroarylalkyl; with the proviso that at least one of R6, R7, R8 or R9 is -OW.
申请公布号 NZ500574(A) 申请公布日期 2000.08.25
申请号 NZ19990500574 申请日期 1999.10.22
申请人 ADIR ET COMPAGNIE 发明人 CASARA, PATRICK;DOREY, GILBERT;LESTAGE, PIERRE;LOCKHART, BRIAN
分类号 C07D215/06;A61K31/47;A61K31/497;A61K31/517;A61P9/10;A61P25/00;A61P25/08;A61P25/16;A61P25/28;A61P27/12;A61P43/00;C07D215/20;C07D221/20;C07D401/06;C07D471/10;(IPC1-7):C07D215/14 主分类号 C07D215/06
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