| 摘要 |
PURPOSE: A fusion of the transcription factor E2F and the retinoblastoma protein RB is provided, along with methods of treatment of hyperproliferative diseases. The fusion is more efficient in repressing transcription of the E2F promoter than RB alone, and that such fusions can cause cell cycle arrest in a variety of cell types. CONSTITUTION: A nucleic acid encoding a fusion polypeptide, the polypeptide comprising a fusion of a DNA binding domain of an E2F transcription factor and a functional growth suppression domain of a retinoblastoma(RB) polypeptide, are provided wherein the fusion polypeptide lacks a functional cyclin A-kinase binding domain of the E2F transcription factor.
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