2,6,9-trisubstituted purine compounds useful as inhibitors of cyclin dependent kinase 2

摘要

The 2,6,9-trisubstituted purine compound or a salt thereof has the formula I wherein: R1 is halogen, or R'-X with X' being -NH-, -O-, thio or sulphonyl moiety; R1' is optionally substituted alkyl, cycloalkyl, cycloheteroalkyl or aryl or heterocycle, aralkyl, heteroaralkyl, heteroalkyl, alkyl alkenyl, alkyl alkynyl or alkyl cycloalkyl; R2 is optionally substituted alkyl, cycloalkyl, or aryl or heterocycle, aralkyl, heteroaralkyl, heteroalkyl, alkyl alkenyl, alkyl alkynyl, alkyl cycloalkyl or alkyl cycloheteroalkyl; R3 is halogen, thio, hydroxyl, alkoxy, alkylthio, alkyl or -NR4R5 and R4 and R5 are independently H, optionally substituted alkyl, alkoxy, amino, amido, carboxyl, optionally substituted cycloalkyl, heterocycle, optionally substituted cycloheteroalkyl, acyl, optionally substituted aryl, aryloxy, heteroaralkyl, alkyl alkenyl, alkyl alkynyl, alkyl cycloalkyl, alkyl cycloheteroalkyl or cyano; limited by the provisos as defined in the specification. A pharmaceutical composition thereof useful for treating rheumatoid arthritis, lupus, type I diabetes, multiple sclerosis, cancer, restenosis, host graft disease or grout.