| 摘要 |
A compound of the formula disclosed are racemates and optically active isomers of substituted aminobutyl derivatives of cyclohexylphenylglycolic acid, including esters, amides and keto isosteres, which possess smooth muscle spasmolytic properties with reduced anticholinergic and cardiodepressive side effects. Wherein; X is oxygen, -NH or methylene; R1 and R2 are independently selected from the group consisting of hydrogen, C1-4alkyl, (CH2)2OH and (CH2)3OH with the proviso that: 1) When X is oxygen: R1 and R2 are not both CH3; R1 and R2 are not both C2H5; R1 and R2 are not both C3H7; R1 is not C2H5, when R2 is hydrogen; R1 and R2 are not both C4H9; and R1 is not CH3 when R2 is C2H5; 2) When X is -NH: R1 is not hydrogen when R2 is CH3 when said compound is in the racemic form; R1 is not hydrogen when R2 is C2H5; R1 and R2 are not both CH3; R1 and R2 are not both C2H5; R1 and R2 are not both C3H7; R1 and R2 are not both C4H9; R1 is not (CH2)2OH when R2 is hydrogen or CH3 or C2H5, when said compound is in the racemic form; and R1 is not (CH2)3OH when R2 is hydrogen or CH3 or C2H5, when said compound is in the racemic form; or 3) When X is methylene: R1 and R2 are not both hydrogen when the compound is in the racemic form or in the R-form; R1 and R2 are not both CH3, when the compound is in the racemic form or in the R-form; R1 and R2 are not both C2H5, when the compound is in the racemic form or in the R-form; R1 is not hydrogen when R2 is CH3; and R1 is not hydrogen when R2 is C2H5 when the compound is in the racemic form or in the R-form.
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