TYPE II TGF-BETHA RECEPTOR/IMMUNOGLOBULIN CONSTANT REGION FUSION PROTEINS

摘要

An isolated transforming growth factor-beta (TGF-beta ) receptor fusion protein (A) that competitively inhibits binding of TGF-beta to TGF-beta receptor, is new. Also claimed are: (1) an isolated polynucleotide encoding, in expression, a TGF-beta type II receptor linked to a protein that is not a TGF-beta type II receptor; (2) a composition comprising (A) in a pharmaceutically acceptable carrier, (A) being in an amount sufficient to inhibit binding of TGF-beta to a TGF-beta ligand; (3) a vector comprising the polynucleotide of (2); and (4) a host cell containing the vector of (3).