method of screening non-pathogenic bacteria capable of binding to tissue adhesion receptors

摘要

The method of selecting non-pathogenic bacterial strains capable of binding to the receptor sites for tissue adhesion of pathogenic bacterial strains comprises: a) bringing the receptors into contact in vitro with a bacterial strain to be tested; b) adding an antibody directed against the receptors, the antibody being optionally labeled in a detectable manner; c) in the case where the antibody is itself not labeled in a detectable manner, adding an agent for detecting the antibody and d) detecting the presence of the complex formed between the antibody and the receptors. The bacterial strains selected n the above method can be used to treat or prevent pathological disorders associated with infection by a pathogenic bacterial strain which bind to the receptors mediating tissue adhesion.