| 摘要 |
PURPOSE: Provided are novel pseudoceramides. More specifically, it relates to synthetic pseudoceramides which can be applied to soaps, shampoos, cosmetic products, food and various emulsified systems, a process for preparing the same, and dermatologic external preparations containing the same. CONSTITUTION: Pseudoceramide derivatives are represented by the formula (I) R1-COCHR2CONR3R4 or the formula (II) R1-CH(OH)CHR2CONR3R4 wherein each of R1 and R2 represents linear or branched alkyl group or alkenyl group having 6-22 carbon atoms; each of R3 and R4 represents hydrogen, methyl, ethyl, propyl, or linear or branched C2-C6 alkyl group having one or more hydroxyl group(s), or monosaccharide, a process for preparing the same, and dermatologic external preparations containing the same. When the pseudoceramide derivatives according to the present invention are applied in a dermatologic external preparation the moisture-retaining property and resilience of skin and hair becomes excellent so that the derivatives are useful in protection of skin-aging. Besides, the derivatives are useful for inducing the formation of lipid layer on damaged skin and for preventing the inhibition of lipid synthesis.
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