摘要 |
Method of producing thiobarbituric acid derivatives of formula IwhereinR1 is SH, S<->M<+ >or CH3S-, and M<+ >is an alkali metal ion, by hydrogenolysis of a compound of formula IIwherein R2 is chlorine or CH3O-, witha) a hydrogenolysis agent in the presence of an inert solvent and by a direct reaction of the hydrogenolysis product with an alkali metal methylate in methanol, orb) with a hydrogenolysis agent in the presence of an inert solvent and in the presence of a methylation reagent, and subsequently with an alkali metal methylate in methanol, as well as the use of these compound of formula I in the production of 7-[(4,6-dimethoxy-pyrimidin-2-yl)thio]-3-methylphthalide. |