发明名称 |
Fiber receptor-independent system for the propagation of adenoviral vectors |
摘要 |
The present invention provides a means for the propagation of adenovirus lacking the native tropism by using genetic methods to modify the fiber protein by addition of a C-terminal tag. The modified virus is then propagated in a cell line transfected with a sequence encoding an artificial receptor for the C-terminal tag on the modified fiber protein. |
申请公布号 |
AU2869300(A) |
申请公布日期 |
2000.08.25 |
申请号 |
AU20000028693 |
申请日期 |
2000.02.03 |
申请人 |
THE UAB RESEARCH FOUNDATION |
发明人 |
DAVID T CURIEL;VICTOR N. KRASNYKH;IGOR DMITRIEV;JOANNE T. DOUGLAS |
分类号 |
C07K14/705;C12N7/01;C12N15/861 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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