| 摘要 |
The present invention provides compounds of formula (I) wherein: X, Y and Z are independently selected from O, S, CH, CH2, N or NR<4>; W is moiety selected from (CH2)n; n= 1-2; R<1>, R<2> are independently, hydrogen, straight chain alkyl (C1-C6), branched chain alkyl (C3-C7), cycloalkyl (C3-C7), alkoxyalkyl (C2-C7), halogen, straight or branched chain alkoxy (C1-C6), hydroxy, CF3, or perfluoroalkyl (C2-C6); R<3> is hydrogen or a straight chain alkyl group (C1-C6), branched chain alkyl (C3-C7), cycloalkyl (C3-C7), alkoxyalkyl (C2-C7), or hydroxyalklyl (C1-C6); R<4> is selected from hydrogen, or lower alkyl (C1-C6); R5 is selected from halogen or hydrogen; or a pharmaceutically acceptable salt thereof; as well as methods and pharmaceutical compositions utilizing these compounds for the treatment of disorder which may be remedied or alleviated by vasopressin agonist activity, including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence, bleeding and coagulation disorders, or temporary delay of urination. |
