发明名称 |
A method for targeted degradation of intracellular proteins (in vivo) or (ex vivo) |
摘要 |
A method for in vivo selective targeted degradation of intracellular proteins in situ by inducing in vivo or ex vivo in cells a production of dual-function protein comprising N-terminal domain as well as a C-terminal domain or delivering the dual-function protein. The N-terminal domain of the dual-function protein destabilizes the target protein and directs its degradation when linked to it through a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within the first 97 amino acids corresponding to the N-terminus of protein antizyme. |
申请公布号 |
AU2753600(A) |
申请公布日期 |
2000.08.25 |
申请号 |
AU20000027536 |
申请日期 |
2000.02.02 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, |
发明人 |
PHILIP COFFINO;XIANQIANG LI |
分类号 |
A61K38/00;A61P35/00;C07K14/435;C07K14/47;C12N9/88;C12N15/62;G01N33/53;G01N33/68 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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