发明名称 |
Microbial process for preparing pravastatin |
摘要 |
The present invention relates to a new microbial process for the preparation of compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6 beta -hydroxylate a compound of Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6 beta -hydroxylate a compound of general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed. |
申请公布号 |
AU3356700(A) |
申请公布日期 |
2000.08.25 |
申请号 |
AU20000033567 |
申请日期 |
2000.02.03 |
申请人 |
INSTITUTE FOR DRUG RESEARCH LTD. |
发明人 |
ATTILA KONYA;ISTVAN BARTA;EVA ILKOY;GYORGY SOMOGYI;GABOR AMBRUS;GYULA HORVATH;KAROLY ALBRECHT;ISTVAN M. SZABO;JULIANNA MOZES NEE SUTO;JANOS SALAT;ATTILA ANDOR;LASZLO BIRINCSIK;SANDOR BOROS;ILDIKO LANG;MARGIT BIDLO NEE IGLOY |
分类号 |
C07B53/00;C07C;C07C61/16;C07C67/02;C07C67/28;C07C67/52;C07C69/02;C07C69/30;C07C69/33;C12N1/14;C12P;C12P7/62;C12R1/645 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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