INHIBITORS OF SEPARIN, METHOD FOR IDENTIFYING THEM AND USES
摘要
Method for identifying compounds that interfere with or modulate sister chromatid separation in animal or plant cells by modulating a protease with separin-like cysteine endopeptidase activity. Inhibitors of separin activity are useful in cancer therapy, to prevent birth defects and to increase ploidy in plants.
申请公布号
WO0048627(A1)
申请公布日期
2000.08.24
申请号
WO2000EP01183
申请日期
2000.02.14
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;UHLMANN, FRANK;NASMYTH, KIM;PETERS, JAN-MICHAEL;WAIZENEGGER, IRENE;BUONOMO, SARA;CLYNE, ROSEMARY