METHOD FOR SCREENING COMPOUND HAVING AFFINITY FOR VITAMIN D RECEPTOR

摘要

A method for screening a vitamin D derivative wherein the blood calcium leve l- elevating effect alone has been relieved or eliminated while sustaining usef ul physiological activities. A method for screening a compound having an affini ty for vitamin D receptor which comprises measuring the activity of a test compound of promoting the VDRE-mediated transcription by vitamin D receptor and the effect of the test compound of inhibiting the activity of the transcription factor of the vitamin D receptor, thereby selecting a compound showing the transcription factor activity inhibitory effect relatively stronger than the VDRE-mediated transcription promoting activity.