| 发明名称 |
A NOVEL ANTI-ANGIOGENIC AGENT COMPRISING AT LEAST ONE KRINGLE REGION AND AN UPSTREAM PRE-ACTIVATION DOMAIN OF PLASMINOGEN |
| 摘要 |
<p>The present invention relates to one or more compositions that inhibit the proliferation and/or migration of endothelial cells. The compositions contain a pre-activation domain ("PAD") from plasminogen (or biologically active fragment thereof) and said at least one kringle region from plasminogen (or biologically active portion thereof). The compositions are useful to treat angiogenic associated disorders.</p> |
| 申请公布号 |
WO0048595(A1) |
申请公布日期 |
2000.08.24 |
| 申请号 |
WO2000US03264 |
申请日期 |
2000.02.08 |
| 申请人 |
BRISTOL-MYERS SQUIBB CO. |
发明人 |
KONDRI, MOHAMMAD, EGHTEDARZADEH;JI, WEIDONG-RICHARD;TRAIL, PAMELA, A. |
| 分类号 |
C12N15/09;A61K38/00;A61K38/48;A61P1/00;A61P9/00;A61P9/10;A61P17/02;A61P17/06;A61P27/00;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C12N9/68;C12P21/02;(IPC1-7):A61K31/40;A61K38/17;C07K14/435;A61K38/46;A61K35/14;A61K38/16;C07K14/00 |
主分类号 |
C12N15/09 |
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