发明名称 |
GENETICALLY ALTERED MESENCHYMAL STEM CELLS AND METHODS OF USE THEREOF |
摘要 |
Genetically altered mesenchymal stem cells include nucleic acid that encodes an immune system suppressor polypeptide which inhibits an immune response to the mesenchymal stem cells in a recipient of the mesenchymal stem cells. Such cells are useful in treating or correcting tissue injury and/or tissue disorders such as connective tissue disorders. The immune system suppressor polypeptide includes complement restriction factors, and enzymes or proteins which, when expressed in a xenogeneic cell, cause the reduction of a xenogeneic epitope on the cell-surface of the xenogeneic cell. |
申请公布号 |
WO0049136(A1) |
申请公布日期 |
2000.08.24 |
申请号 |
WO2000US03963 |
申请日期 |
2000.02.16 |
申请人 |
UNITED STATES SURGICAL |
发明人 |
GRUSKIN, ELLIOTT, A.;TAWIL, NABIL;GEIS, DAVID |
分类号 |
A61K35/12;C12N5/0775 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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